Ease to use and extremely powerful in both PVE and PVP, Osteo Striga immediately became a lot of players’ favorite Exotic.
Its poison-spreading effect makes it one of the best ad clear primaries in PVE, and its enemy-tracking bullets make it an easy-to-use option in PVP. Plus, its catalyst is S-tier, further cementing it into one of the best weapons in Destiny 2.
This guide will show you how to get the weapon, what are the best rolls, and equally important, how to find its catalyst.
| Art | Weapon | Archetype | Rarity | Ammo | Element | Requirements | In loot pool? | Ammo? | Element? | Tier | Excels | Source | Available? | Requires | Released | Slot | Craftable? |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Osteo Striga | Exotic | Exotic | Primary | Kinetic | The Witch Queen | Yes |  |  | Best ❘ S | PvE + PvP | Deluxe Edition |  |  The Witch Queen | Season 16 | Kinetic | Craftable |
How to get the Osteo Striga in 2022
The Osteo Striga is only available to players who own the Deluxe Edition of The Witch Queen expansion. Owning the Deluxe edition is only the first step, though, as you’ll need to beat the Witch Queen campaign too. Once completed, you can head over to the Enclave on the Throne World, and craft the weapon for yourself.
Osteo Striga God Rolls can be crafted here
You’ll only be able to choose from a limited selection of perks the time around and you’ll have to level up the weapon in order to unlock more perks, and eventually, the Catalyst.
However, the weapon is absolutely great, even at level 1.
How good is Osteo Striga in 2022
Osteo Striga is one of the best and easiest to use PVE weapons in the entire game. In fact, even players with disabilities praise it, as it doesn’t require a perfect aim to be effective.
And once you unlock its catalyst, it becomes even more powerful.
| Name | Type | Ammo type | Element | Rank | Excels | Source | Weapon ❘ Type | Tier rank | Source ❘ Requires | Final Verdict |
|---|---|---|---|---|---|---|---|---|---|---|
| Osteo Striga | Submachine Gun | Primary | Kinetic | S › Best | PVE | Exotic Quest | Osteo Striga | Submachine Gun | Best ❘ S Excels in: PVE | Exotic Quest The Witch Queen | Slot:  Exotic Perk: "Fires a stream of sentient, toxic projectiles that track the targeted enemy. Landing a final blow or multiple-precision hits triggers a burst that poisons nearby targets." ► This SMG is so damn powerful, it almost feel like cheating. The tracking of its projectiles is always on point, the area of effect damage is massive, and with the catalyst, its uptime is extremely high. Bottom line, the Osteo Striga is the best craftable weapon right now and a monster in PVE. |
Where it shines: The more red-bar enemies there are, the more damage its spread poison will deal. When used properly, you can wipe entire hordes of low-health enemies in an instant.
Where it doesn’t: If you’re facing hard-to-kill red bar enemies (in say, Master or Grandmaster content), Osteo Striga, just as Trinity Ghoul, will lose most of its killing potential.
Best Osteo Striga Rolls for PvE and PvP
Once you’ve crafted Osteo Striga, it will up to you to level it up and unlock all the different Barrel, Magazine, and Stock perks:
Osteo Striga god rolls, Destiny 2
Among the several strong possible combinations out there, these are our favorites, the combinations we consider the god rolls.
Osteo Striga PvE god roll
This is a perfectly balanced SMG for PvE, featuring excellent handling and stability. It doesn’t have that much Reload, but the Reload is not as irrelevant because of the Catalyst.
- Fluted Barrel: Ultra-light barrel. Greatly increases handling speed. Slightly increases stability
- Flared Magwell: Optimized for fast reloading. Slightly increases stability. Greatly increases reload speed
- Short-Action Stock: This weapon is especially easy to grip. Greatly increases handling speed
Thanks to Ekuegan for this recommendation!
Osteo Striga PvP god roll
For PvP, we’re going for a roll with a little more range and more stability, as you want to be able to hit those 7 shots (required for the kill) as reliably as possible:
- Polygonal Rifling: Barrel optimized for recoil reduction. Increases stability
- Accurized Rounds: This weapon can fire longer distances. Increases range
- Hand-Laid Stock: This weapon is optimized for recoil control. Increases stability
Osteo Striga’s best perks
Unlike some Legendary weapons that usually have a perk or two above the rest, the Osteo Striga offers a fair selection of good perks. According to Light.gg, these are the most popular perks based on more than 100,000 copies of the weapon:
| Barrel | Magazine | Stock |
| Polygonal Rifling (28% usage) | Flared Magwell (30.5% usage) | Hand-Laid Stock (47.8% usage) |
Osteo Striga’s best perks, Destiny 2
Best Osteo Striga build
A build is absolutely not required for this weapon to be effective. Osteo Striga is extremely lethal and one of the best weapons in the game, especially with the catalyst. However, if you want to take it to the next level, you can pair it with the Warlock’s Necrotic Grip exotic.
| Armor | Class | Type | Requirements | Source | Released | Requires | Exotic Perk |
|---|---|---|---|---|---|---|---|
 Necrotic Grip | Warlock | Arms | Beyond Light | Lost Sectors | Season 12 |  Beyond Light | Exotic Perk: "Damaging combatants envenoms them with poison that deals increasing damage over time. Defeating a poisoned combatant spreads the condition to nearby targets." |
The best build for Osteo Striga involves using the Necrotic Grip Exotic gauntlets. With Necrotic Grip, defeating poisoned enemies spreads the condition to nearby targets. In this case, every enemy you defeat using Osteo Striga will spread the poison even further.
This combination is so broken, that you can easily clear entire rooms of enemies barely lifting a finger.
Osteo Striga catalyst: Where to find it?
The catalyst for the Osteo Striga Exotic SMG can be purchased at the Enclave Relic on the Throne World as soon as Weapon Level 10 has been reached.
| Name | Type | Slot | Catalyst Rank | Catalyst Source | Available? | Requirements | Catalyst | Tier | Source ❘ DLC | How to unlock it | Catalyst effect | Released |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Osteo Striga | Submachine Gun | Kinetic | A › Strong | Crafting Relic | Yes | The Witch Queen |  Osteo Striga | Submachine Gun | Strong ❘ A | Crafting Relic The Witch Queen | ► Reach Level 10 to purchase at Crafting Relic | ► Poison final blows return ammo to the magazine. | Season 16 |
Osteo Striga Catalyst, Destiny 2
This is the new perk unlocked with its Catalyst:
- Poison final blows return ammo to the magazine.
How to unlock the catalyst?
Unlike every other Catalyst in Destiny 2, Osteo Striga’s is unlocked as soon as you purchase it and reshape the weapon at the Relic.
Your turn
If you don’t have the Osteo Striga already, I suggest you finish that (amazing) Witch Queen campaign, craft an Osteo Striga for yourself, and level it up fast. Believe, that weapon with its catalyst is a game changer and you’ll be surprised how strong it currently is in PvE!
I have one with catalyst and I have it leveled up past 120. I use this all the time because I play mostly solo. I agree that it is one of the best guns in the game.