Destiny 2 Osteo Striga: God Rolls, Catalyst & How to get it

by | Mar 15, 2024

Ease to use and extremely powerful, Osteo Striga instantly became many players’ favorite Exotic. Its poison-spreading effect makes it one of the best ad-clear primaries in PvE, and its enemy-tracking bullets make it an easy-to-use option in PvP. Plus, its catalyst is S-tier, further cementing it into one of the best weapons in Destiny 2.

This guide will show you how to get the weapon, the best rolls, and how to find its catalyst.

How to get the Osteo Striga

The Osteo Striga was previously only available to players who owned the Deluxe Edition of The Witch Queen expansion. But nowadays, Osteo Striga is rewarded to all players who finish The Witch Queen campaign (owning the Deluxe edition is no longer required).

Once The Witch Queen campaign is completed, you can head over to the Enclave and craft the weapon.

The weapon costs:

  • 7 Resonant Alloy
  • 15,000 Glimmer
  • 2,375 Resonant Elements
  • 1 Ascendant Alloy

You’ll only be able to choose from a limited selection of perks the first time around, and you’ll have to level up the weapon to unlock more perks and, eventually, the Catalyst. However, the weapon is fantastic, even at level 1.

Osteo Striga cost

How to get the Osteo Striga, Destiny 2

How good is the Osteo Striga

Osteo Striga features the following Exotic perks:

  • Screaming Swarm: Fires a stream of sentient, toxic projectiles that track the targeted enemy.
  • Toxic Overload: Landing a final blow or multiple precision hits triggers a burst that poisons nearby targets.

This weapon has it all. It has enemy-tracking bullets, a poison-spreading effect, and just feels great to use. In PvE, its easy and consistent ad-clear potential rivals that of Huckleberry. Osteo Striga is also way more fun and flashy than The Huckleberry, boosting its ranking even more.

In PvP, the main draw to this weapon is its tracking bullets, which allow it to compete at longer ranges. The tracking feature also makes Osteo Striga significantly easier to use compared to other options, making it great for new players.

Lastly, the weapon is craftable, meaning you can customize the weapon however you’d like and secure your very own Osteo Striga god roll. All in all, there isn’t much to hate about this weapon. Its ad-clear, ease-of-use, and fun factor are all unrivaled, making it the best SMG currently in the game.

S-tier for PvE A-tier for PvP

Osteo Striga God Rolls for PvE and PvP

Once you’ve crafted Osteo Striga, it will be up to you to level it up and unlock all the different Barrel, Magazine, and Stock perks.

Osteo Striga Destiny 2 featured

Osteo Striga God rolls, Destiny 2

Osteo Striga PvE god roll

  • Barrel: Fluted Barrel
  • Magazine: Flared Magwell
  • Stock: Short-Action Stock

This is a perfectly balanced SMG for PvE, featuring excellent handling and stability. It doesn’t have much Reload, but Reload is less relevant because of the Catalyst.

Osteo Striga PvP god roll

  • Barrel: Polygonal Rifling
  • Magazine: Accurized Rounds
  • Stock: Hand-Laid Stock

For PvP, we prefer a roll with a little more range and more stability, as you want to be able to hit those seven shots (required for the kill) as reliably as possible:

Osteo Striga’s best Perks

Unlike some Legendary weapons that usually have a perk or two above the rest, the Osteo Striga offers a fair selection of good perks. According to, these are the most popular perks based on more than 100,000 copies of the weapon:

Barrel Magazine Stock
Polygonal Rifling (28% usage) Flared Magwell (30.5% usage) Hand-Laid Stock (47.8% usage)

Best Osteo Striga build

A dedicated build is definitely not required for this weapon to be effective. Osteo Striga is highly lethal and one of the best weapons in the game, especially with the catalyst. However, if you want to take it to the next level, you can pair it with a specific Warlock exotic.

ArmorClassTypeRequirementsSourceReleasedRequiresExotic Perk
Necrotic Grip Destiny 2 art

Necrotic Grip

WarlockArmsBeyond LightLost SectorsSeason 12Beyond Light Destiny 2 icon
Beyond Light
Exotic Perk: "Damaging combatants envenoms them with poison that deals increasing damage over time. Defeating a poisoned combatant spreads the condition to nearby targets."

The best build for Osteo Striga involves using the Necrotic Grip Exotic gauntlets. With Necrotic Grip, defeating poisoned enemies spreads the condition to nearby targets. In this case, every enemy you defeat using Osteo Striga will spread the poison even further.

This combination is so broken that you can easily clear entire rooms of enemies, barely lifting a finger.

How to get the Osteo Striga Catalyst

The catalyst for the Osteo Striga can be purchased at the Enclave Relic on the Throne World as soon as Weapon Level 10 has been reached.

Osteo Striga Catalyst Destiny 2 featured

Osteo Striga Catalyst, Destiny 2

The catalyst unlocks the following perk:

  • Osteo Striga Catalyst: Poison final blows return ammo to the magazine.

Unlike every other Catalyst in Destiny 2, Osteo Striga’s is unlocked as soon as you purchase it and use it to when reshaping the weapon at the Relic.

Before you go…

Are you looking for other top-tier Exotics with random rolls? We cover the top Dead Man’s Tale God rolls here. 

About The Author

Ric Molina
Ric Molina
I've been covering gaming since 2012, and some of my work has been featured by large brands, including, Forbes, Rock Paper Shotgun, and more. I've been obsessed with Destiny 2 (and now Diablo 4) for years now, and I hope to provide new and returning players with the guides and resources I wish I had when I first started.
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  1. William Ricci

    I have one with catalyst and I have it leveled up past 120. I use this all the time because I play mostly solo. I agree that it is one of the best guns in the game.

  2. CrakHeadSoup

    I have one that’s Level 397 with 38,398 kills…

    Yeah it’s Way Past a God Roll and Doesn’t conform to the prescribed..

    I tried everything suggested and found this to be The One..

    Short Action Stock, Toxic Overload, Flared Magwell, and Forged Rifling .. Of course you need the

    Catalyst and a bit of work to get you there but the Ground Shakes at my approach..

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