Ease to use and extremely powerful in both PvE and PvP, Osteo Striga instantly became a lot of players’ favorite Exotic. Its poison-spreading effect makes it one of the best ad-clear primaries in PvE, and its enemy-tracking bullets make it an easy-to-use option in PvP. Plus, its catalyst is S-tier, further cementing it into one of the best weapons in Destiny 2.
This guide will show you how to get the weapon, the best rolls, and how to find its catalyst.
| Art | Weapon | Archetype | Rarity | Ammo | Element | Requirements | In loot pool? | Ammo? | Element? | Tier | Excels | Source | Craftable? | Requires | Released | Slot | Can be Crafted? | Best of? | Top Perk? |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Osteo Striga | Exotic | Exotic | Primary | Kinetic | The Witch Queen | Yes |  |  Kinetic | Best ❘ S | PvE + PvP | The Witch Queen Campaign |   |  The Witch Queen | Season 16 | Kinetic | Craftable | Top-tier |
How to get the Osteo Striga this season
The Osteo Striga was previously only available to players who owned the Deluxe Edition of The Witch Queen expansion. But nowadays, Osteo Striga is rewarded to all players who finish The Witch Queen campaign (owning the Deluxe edition is no longer required).
Once The Witch Queen campaign too completed, you can head over to the Enclave and craft the weapon.
How to get the Osteo Striga
You’ll only be able to choose from a limited selection of perks the first time around, and you’ll have to level up the weapon to unlock more perks and, eventually, the Catalyst. However, the weapon is fantastic, even at level 1.
Osteo Striga cost
To purchase a level 1 Osteo Striga at the Enclave, you’ll need the following:
- 7 Resonant Alloy
- 15,000 Glimmer
- 2,375 Resonant Elements
- 1 Ascendant Alloy
How good is the Osteo Striga today?
Osteo Striga is one of the best and easiest-to-use PVE weapons in the entire game. Even players with disabilities praise it, as it doesn’t require a perfect aim to be effective.
And once you unlock its catalyst, which grants it virtually infinite ammo, it becomes even more powerful.
✅ Where it shines: The more red-bar enemies there are, the more damage its spread poison will deal. When used properly, you can instantly wipe entire hordes of low-health enemies.
⛔️ Where it doesn’t: If you’re facing hard-to-kill red bar enemies (Master or Grandmaster content), Osteo Striga, like Trinity Ghoul, will lose most of its killing potential.
Best Osteo Striga Rolls for PvE and PvP
Once you’ve crafted Osteo Striga, it will be up to you to level it up and unlock all the different Barrel, Magazine, and Stock perks:
Osteo Striga god rolls, Destiny 2
Among the several strong combinations out there, these are our favorites, the combinations we consider the god rolls.
Osteo Striga PvE god roll
This is a perfectly balanced SMG for PvE, featuring excellent handling and stability. It doesn’t have that much Reload, but Reload is not as irrelevant because of the Catalyst.
- Fluted Barrel: Ultra-light barrel. Greatly increases handling speed. Slightly increases stability
- Flared Magwell: Optimized for fast reloading. Slightly increases stability. Greatly increases reload speed
- Short-Action Stock: This weapon is especially easy to grip. Greatly increases handling speed
Thanks to Ekuegan for this recommendation!
Osteo Striga PvP god roll
For PvP, we prefer a roll with a little more range and more stability, as you want to be able to hit those seven shots (required for the kill) as reliably as possible:
- Polygonal Rifling: Barrel optimized for recoil reduction. Increases stability
- Accurized Rounds: This weapon can fire longer distances. Increases range
- Hand-Laid Stock: This weapon is optimized for recoil control. Increases stability
Osteo Striga’s best perks
Unlike some Legendary weapons that usually have a perk or two above the rest, the Osteo Striga offers a fair selection of good perks. According to Light.gg, these are the most popular perks based on more than 100,000 copies of the weapon:
| Barrel | Magazine | Stock |
| Polygonal Rifling (28% usage) | Flared Magwell (30.5% usage) | Hand-Laid Stock (47.8% usage) |
Best Osteo Striga build
A dedicated build is definitely not required for this weapon to be effective. Osteo Striga is highly lethal and one of the best weapons in the game, especially with the catalyst. However, if you want to take it to the next level, you can pair it with a specific Warlock exotic.
| Armor | Class | Type | Requirements | Source | Released | Requires | Exotic Perk |
|---|---|---|---|---|---|---|---|
  Necrotic Grip | Warlock | Arms | Beyond Light | Lost Sectors | Season 12 |  Beyond Light | Exotic Perk: "Damaging combatants envenoms them with poison that deals increasing damage over time. Defeating a poisoned combatant spreads the condition to nearby targets." |
The best build for Osteo Striga involves using the Necrotic Grip Exotic gauntlets. With Necrotic Grip, defeating poisoned enemies spreads the condition to nearby targets. In this case, every enemy you defeat using Osteo Striga will spread the poison even further.
This combination is so broken that you can easily clear entire rooms of enemies, barely lifting a finger.
Where to find the Osteo Striga catalyst
The catalyst for the Osteo Striga Exotic SMG can be purchased at the Enclave Relic on the Throne World as soon as Weapon Level 10 has been reached.
| Name | Type | Slot | Catalyst Rank | Catalyst Source | Available? | Requirements | Catalyst | Tier | Source ❘ DLC | How to unlock | Catalyst effect | Released |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Osteo Striga | Submachine Gun | Kinetic | A › Strong | Crafting Relic | Yes | The Witch Queen |  Osteo Striga | Submachine Gun | Strong ❘ A | Crafting Relic The Witch Queen | ► Reach Level 10 to purchase at Crafting Relic | ► Poison final blows return ammo to the magazine. | Season 16 |
Osteo Striga Catalyst, Destiny 2
This is the new perk unlocked with its Catalyst:
- Poison final blows return ammo to the magazine.
How to unlock the catalyst?
Unlike every other Catalyst in Destiny 2, Osteo Striga’s is unlocked as soon as you purchase it and reshape the weapon at the Relic.
Your turn
If you don’t have the Osteo Striga already, I suggest you finish that (amazing) Witch Queen campaign, craft an Osteo Striga for yourself, and level it up fast. Believe, that weapon with its catalyst is a game changer, and you’ll be surprised how strong it currently is in PvE!
I have one with catalyst and I have it leveled up past 120. I use this all the time because I play mostly solo. I agree that it is one of the best guns in the game.