Osteo Striga Exotic SMG Guide: God Rolls for PvE & PvP

by | Jun 16, 2022 | Weapons

Feeling extremely nice to use in both PVE and PVP, Osteo Striga immediately became a lot of players’ favorite exotic.

Its poison-spreading effect makes it one of the best ad clear primaries in PVE, and its enemy-tracking bullets make it an easy-to-use option in PVP. Plus, its catalyst is S-tier, further cementing it into one of the best weapons in Destiny 2.

This guide will show you how to get the weapon, what are the best rolls, and equally importantly, how to find its catalyst.

Osteo Striga Destiny 2 artOsteo StrigaExoticExoticPrimaryKineticThe Witch QueenYesPrimary ammo Destiny 2 PrimaryKinetic symbol Destiny 2 Kinetic


PVE + PVPDeluxe Edition
The Witch Queen
Season 16KineticCraftable

How to get the Osteo Striga in 2022

The Osteo Striga is only available to players who own the Deluxe Edition of The Witch Queen expansion. Owning the Deluxe edition is only the first step, though, as you’ll need to beat the Witch Queen campaign too. Once completed, you can head over to the Enclave on the Throne World, and craft the weapon for yourself.

Weapon crafting Destiny 2 900p

Osteo Striga God Rolls can be crafted here

You’ll only be able to choose from a limited selection of perks this time around, as you’ll have to level up the weapon in order to unlock more perks and the catalyst.

However, the weapon is absolutely great, even at level 1.

How good is Osteo Striga in 2022

Osteo Striga is one of the best and easiest to use PVE weapons in the entire game. In fact, even players with disabilities praise it, as it doesn’t require a perfect aim to be effective.

And once you unlock its catalyst, it becomes even more powerful.

NameTypeAmmo typeElementRankExcelsSourceWeapon ❘ TypeTier rankSource ❘ RequiresFinal Verdict
Osteo StrigaSubmachine GunPrimaryKineticS › BestPVEExotic QuestOsteo Striga Destiny 2 art
Osteo Striga
| Submachine Gun


Excels in:
Exotic Quest

The Witch Queen
Slot: Kinetic symbol Destiny 2 Kinetic | Ammo: Destiny 2 special ammo Special

Exotic Perk: "Fires a stream of sentient, toxic projectiles that track the targeted enemy. Landing a final blow or multiple-precision hits triggers a burst that poisons nearby targets."

► This SMG is so damn powerful, it almost feel like cheating. The tracking of its projectiles is always on point, the area of effect damage is massive, and with the catalyst, its uptime is extremely high. Bottom line, the Osteo Striga is the best craftable weapon right now and a monster in PVE.

Where it shines: The more red-bar enemies there are, the more damage its spread poison will deal. When used properly, you can wipe entire hordes of low-health enemies in an instant.

Where it doesn’t: If you’re facing hard-to-kill red bar enemies (in say, Master or Grandmaster content), Osteo Striga, just as Trinity Ghoul, will lose most of its killing potential.

Osteo Striga God Rolls for PvE and PvP

Once you’ve crafted Osteo Striga, it will up to you to level it up and unlock all the different Barrel, Magazine and Stock perks:

Osteo Striga god rolls, Destiny 2

Among the several strong possible combinations out there, these are our favorites, the combinations we consider the god rolls.

Osteo Striga PvE god roll

This is a perfectly balanced SMG for PvE, featuring excellent handling and stability. It doesn’t have that much Reload, but the Reload is not as irrelevant because of the Catalyst.

  • Fluted Barrel: Ultra-light barrel. Greatly increases handling speed. Slightly increases stability
  • Flared Magwell: Optimized for fast reloading. Slightly increases stability. Greatly increases reload speed
  • Short-Action Stock: This weapon is especially easy to grip. Greatly increases handling speed

Thanks to Ekuegan for this recommendation!

Osteo Striga PvP god roll

For PvP, we’re going for a roll with a little more range and more stability, as you want to be able to hit those 7 shots (required for the kill) as reliably as possible:

  • Polygonal Rifling: Barrel optimized for recoil reduction. Increases stability
  • Accurized Rounds: This weapon can fire longer distances. Increases range
  • Hand-Laid Stock: This weapon is optimized for recoil control. Increases stability

Osteo Striga catalyst: Where to find it?

The catalyst for the Osteo Striga Exotic SMG can be purchased at the Enclave Relic on the Throne World as soon as Weapon Level 10 has been reached.

NameTypeSlotCatalyst RankCatalyst SourceAvailable?RequirementsCatalystTierSource ❘ DLCHow to unlock itCatalyst effectReleased
Osteo StrigaSubmachine GunKineticA › StrongCrafting RelicYesThe Witch QueenOsteo Striga Catalyst Destiny 2 art
Osteo Striga
| Submachine Gun


Crafting Relic

The Witch Queen
► Reach Level 10 to purchase at Craf► Poison final blows return ammo to the magazine.Season 16
Osteo Striga Catalyst Destiny 2 featured

Osteo Striga Catalyst, Destiny 2

This is the new perk unlocked with its Catalyst:

  • Poison final blows return ammo to the magazine.

How to unlock the catalyst?

Unlike every other Catalyst in Destiny 2, Osteo Striga’s is unlocked as soon as you purchase it and reshape the weapon at the Relic.

Your turn

If you don’t have the Osteo Striga already, I suggest you finish that (amazing) Witch Queen campaign, craft an Osteo Striga for yourself, and level it up fast. Believe, that weapon with its catalyst is a game changer and you’ll be surprised how strong it currently is in PvE!

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