Osteo Striga Exotic SMG: God Rolls and Catalyst

by | Apr 14, 2023

Ease to use and extremely powerful in both PvE and PvP, Osteo Striga instantly became a lot of players’ favorite Exotic. Its poison-spreading effect makes it one of the best ad-clear primaries in PvE, and its enemy-tracking bullets make it an easy-to-use option in PvP. Plus, its catalyst is S-tier, further cementing it into one of the best weapons in Destiny 2.

This guide will show you how to get the weapon, the best rolls, and how to find its catalyst.

ArtWeaponArchetypeRarityAmmoElementRequirementsIn loot pool?Ammo?Element?TierExcelsSourceCraftable?RequiresReleasedSlotCan be Crafted?Best of?Top Perk?
Osteo Striga art Osteo StrigaExoticExoticPrimaryKineticThe Witch QueenYesPrimary ammo Destiny 2 PrimaryKinetic symbol Destiny 2 Kinetic


PvE + PvPThe Witch Queen CampaignCheckmark icon V3The Witch Queen Destiny 2 icon
The Witch Queen
Season 16KineticCraftableTop-tier

How to get the Osteo Striga this season

The Osteo Striga was previously only available to players who owned the Deluxe Edition of The Witch Queen expansion. But nowadays, Osteo Striga is rewarded to all players who finish The Witch Queen campaign (owning the Deluxe edition is no longer required).

Once The Witch Queen campaign too completed, you can head over to the Enclave and craft the weapon.

Osteo Striga cost

How to get the Osteo Striga

You’ll only be able to choose from a limited selection of perks the first time around, and you’ll have to level up the weapon to unlock more perks and, eventually, the Catalyst. However, the weapon is fantastic, even at level 1.

Osteo Striga cost

To purchase a level 1 Osteo Striga at the Enclave, you’ll need the following:

  • 7 Resonant Alloy
  • 15,000 Glimmer
  • 2,375 Resonant Elements
  • 1 Ascendant Alloy

How good is the Osteo Striga today?

Osteo Striga is one of the best and easiest-to-use PVE weapons in the entire game. Even players with disabilities praise it, as it doesn’t require a perfect aim to be effective.

And once you unlock its catalyst, which grants it virtually infinite ammo, it becomes even more powerful.

✅ Where it shines: The more red-bar enemies there are, the more damage its spread poison will deal. When used properly, you can instantly wipe entire hordes of low-health enemies.

⛔️ Where it doesn’t: If you’re facing hard-to-kill red bar enemies (Master or Grandmaster content), Osteo Striga, like Trinity Ghoul, will lose most of its killing potential.

Best Osteo Striga Rolls for PvE and PvP

Once you’ve crafted Osteo Striga, it will be up to you to level it up and unlock all the different Barrel, Magazine, and Stock perks:

Osteo Striga Destiny 2 featured

Osteo Striga god rolls, Destiny 2

Among the several strong combinations out there, these are our favorites, the combinations we consider the god rolls.

Osteo Striga PvE god roll

This is a perfectly balanced SMG for PvE, featuring excellent handling and stability. It doesn’t have that much Reload, but Reload is not as irrelevant because of the Catalyst.

  • Fluted Barrel: Ultra-light barrel. Greatly increases handling speed. Slightly increases stability
  • Flared Magwell: Optimized for fast reloading. Slightly increases stability. Greatly increases reload speed
  • Short-Action Stock: This weapon is especially easy to grip. Greatly increases handling speed

Thanks to Ekuegan for this recommendation!

Osteo Striga PvP god roll

For PvP, we prefer a roll with a little more range and more stability, as you want to be able to hit those seven shots (required for the kill) as reliably as possible:

  • Polygonal Rifling: Barrel optimized for recoil reduction. Increases stability
  • Accurized Rounds: This weapon can fire longer distances. Increases range
  • Hand-Laid Stock: This weapon is optimized for recoil control. Increases stability

Osteo Striga’s best perks

Unlike some Legendary weapons that usually have a perk or two above the rest, the Osteo Striga offers a fair selection of good perks. According to, these are the most popular perks based on more than 100,000 copies of the weapon:

Barrel Magazine Stock
Polygonal Rifling (28% usage) Flared Magwell (30.5% usage) Hand-Laid Stock (47.8% usage)

Best Osteo Striga build

A dedicated build is definitely not required for this weapon to be effective. Osteo Striga is highly lethal and one of the best weapons in the game, especially with the catalyst. However, if you want to take it to the next level, you can pair it with a specific Warlock exotic.

ArmorClassTypeRequirementsSourceReleasedRequiresExotic Perk
Necrotic Grip Destiny 2 art

Necrotic Grip

WarlockArmsBeyond LightLost SectorsSeason 12Beyond Light Destiny 2 icon
Beyond Light
Exotic Perk: "Damaging combatants envenoms them with poison that deals increasing damage over time. Defeating a poisoned combatant spreads the condition to nearby targets."

The best build for Osteo Striga involves using the Necrotic Grip Exotic gauntlets. With Necrotic Grip, defeating poisoned enemies spreads the condition to nearby targets. In this case, every enemy you defeat using Osteo Striga will spread the poison even further.

This combination is so broken that you can easily clear entire rooms of enemies, barely lifting a finger.

Where to find the Osteo Striga catalyst

The catalyst for the Osteo Striga Exotic SMG can be purchased at the Enclave Relic on the Throne World as soon as Weapon Level 10 has been reached.

NameTypeSlotCatalyst RankCatalyst SourceAvailable?RequirementsCatalystTierSource ❘ DLCHow to unlockCatalyst effectReleased
Osteo StrigaSubmachine GunKineticA › StrongCrafting RelicYesThe Witch QueenOsteo Striga Catalyst Destiny 2 art
Osteo Striga
| Submachine Gun


Crafting Relic
The Witch Queen Destiny 2 icon
The Witch Queen
► Reach Level 10 to purchase at Crafting Relic► Poison final blows return ammo to the magazine.Season 16
Osteo Striga Catalyst Destiny 2 featured

Osteo Striga Catalyst, Destiny 2

This is the new perk unlocked with its Catalyst:

  • Poison final blows return ammo to the magazine.

How to unlock the catalyst?

Unlike every other Catalyst in Destiny 2, Osteo Striga’s is unlocked as soon as you purchase it and reshape the weapon at the Relic.

Your turn

If you don’t have the Osteo Striga already, I suggest you finish that (amazing) Witch Queen campaign, craft an Osteo Striga for yourself, and level it up fast. Believe, that weapon with its catalyst is a game changer, and you’ll be surprised how strong it currently is in PvE!

About The Author

Ric Molina
Ric Molina
I've been covering gaming since 2012, and some of my work has been featured by large brands, including, Forbes, Rock Paper Shotgun, and more. I've been obsessed with Destiny 2 for years now, and I hope to provide new and returning players with the guides and resources I wish I had when I first started.
More from Ric Molina
1 Comment
  1. William Ricci

    I have one with catalyst and I have it leveled up past 120. I use this all the time because I play mostly solo. I agree that it is one of the best guns in the game.

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